year 1, Issue 3 (9-2015)                   jicr 2015, 1(3): 97-108 | Back to browse issues page

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Hajihashemi S, Aghaee Motealeghi Z, Mahboobeh A, Rahbari A. Adenosine Improved Indices of Gentamicin-Induced Nephrotoxicity in Rats. jicr. 2015; 1 (3) :97-108
MD Arak University of Medical Sciences
Abstract:   (621 Views)

Introduction: Gentamicin is an aminoglycoside antibiotic used on treatment of gram-negative bacterial infections; however, due to its adverse effects such as nephrotoxicity, its application has been curtailed. Thus, this study aimed to evaluate therapeutic effects of adenosine on gentamicin-induced nephrotoxicity.

Methods: Thirty five male Wistar rats were divided into five groups of control, gentamicin, adenosine, concurrent gentamicin and adenosine, and post-gentamicin adenosine treatment groups (n=7 for each group). Afterwards, systolic blood pressure, renal blood flow (RBF), as well as urea, creatinine, sodium, potassium, and osmolality levels were quantified. Malondialdehyde (MDA) and ferric

reducing antioxidant power (FRAP) biochemical analyses were also performed on renal tissue.

Results: Concurrent adenosine treatment could significantly inhibit the enhanced levels of sodium and MDA excretions, and compensated for attenuated RBF and FRAP levels caused by gentamicin. In the post-treatment adenosine group, compared to the gentamicin group, elevated relative excretions of sodium, potassium, and MDA, induced by gentamicin treatment, were significantly reduced and urinary excretion of urea was increased.

Conclusion: Adenosine could diminish gentamicin-induced nephrotoxicity through anti-inflammatory effects, vasodilation, and attenuating oxidative stress.

Full-Text [PDF 432 kb]   (281 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/10/6 | Accepted: 2016/04/6 | Published: 2016/04/6

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