year 2, Issue 1 (8-2016)                   jicr 2016, 2(1): 168-173 | Back to browse issues page

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zarinfar N, Cyrus A, sharafkhah M, Akbari M. Antibiotic Resistance Profile of Gram-Positive Bacteria Isolated from Inpatients of an Academic and a Private Hospital in Arak, Central Iran, 2013-2014. jicr. 2016; 2 (1) :168-173
Medical student, School of Medicine, Students Research Committee, Arak University of Medical Sciences, Arak/Iran
Abstract:   (1571 Views)

Introduction: Our country's per capita consumption of antibiotics and especially third-generation cephalosporins is significant and has resulted in emergence of new drug resistant strains. The aim of this study was to investigate Antibiotic Resistance Profile of Gram-Positive Bacteria Isolated from Inpatients of an Academic and a Private hospital in the Arak, Iran.

Material and Methods: This cross-sectional study was conducted for a year (June 2013 to June 2014), and included all cases referred to Amir Almomenin (academic hospital) and Imam Khomeini hospital (private hospital) microbiology laboratories. Gram-positive organisms pattern, were tested for sensitivity to penicillin, oxacillin, ampicillin, TMP-SMX (trimethoprim-sulfamethoxazole), rifampin, vancomycin, clindamycin, ciprofloxacin and gentamicin by the disk diffusion method.

Results: From the 846 specimens of patients in both hospitals, 690 (81.6%) samples were from Amir Almomenin Hospital and 156 (18.4%) cases from Imam Khomeini Hospital, of which, 326 samples (38.5%) were gram-positive and 520 samples (61.5%) were gram-negative. Of the 326 samples of Gram-positive bacteria, 61.3% were coagulase-negative Staphylococcus, 13.5% enterococci and 5.5% Staphylococcus aureus. The prevalence of gram-positive organisms in Amir Almomenin Hospital (academic Hospital) was 84.4% and in Imam Khomeini Hospital (private hospital) 15.6% (P=0.34). Also, the specific resistance components in the public hospital were significantly higher than the private hospital. (P<0.001).

Conclusion: Antibiotic Resistance Profile of gram positive organisms isolated from the two hospitals were significantly different, and the profile of specific resistances in two academic and non-academic hospitals we also discovered significant differences. Therefore, a care program for reviewing and monitoring of the regional resistance patterns is recommended.

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Type of Study: Research | Subject: Special
Received: 2015/10/24 | Accepted: 2016/08/24 | Published: 2016/08/24

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