year 1, Issue 2 (6-2015)                   jicr 2015, 1(2): 72-79 | Back to browse issues page

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Goodarzi D, Cyrus A, Aghamohammadi J, Sadeghi B. Efficacy of Gabapentin for Prevention of Postoperative Catheter-related Bladder Discomfort in Patients Undergoingopens prostatectomy. jicr. 2015; 1 (2) :72-79
Abstract:   (1378 Views)

Introduction: Catheter-related bladder discomfort (CRBD) secondary to catheterization of urinary bladder is distressing. The aim of our study was, to evaluate gabapentin for preventing CRBD and pain severity in patients undergoing open prostatectomy.

Methods: Forty-two patients undergoing open prostatectomy were randomly allocated to 2 intervention and placebo groups. First group received stat dose of 300 mg and 100 mg q8 h of gabapentin and the other one received placebo. The patients were observed for the incidence and severity of CRBD in the postoperative period and pain severity (VAS index). Amount of morphine that patient might need, were recorded. This trial is registered at at number IRCT2014063017811 N4.Despite expected, intervention cases showed significantly decrease in incidence and severity of CRBD at hour 6 and 24 after surgery compared with placebo subjects. Although significant correlation was observed with pain severity and patient who received gabapentin showed lower mean of VAS score in comparison with placebo group (P&le0.05).
Conclusions: Gabapentin probably controls detrusor muscle over activity by modulating the afferent input from the bladder and the excitability of the sacral reflex center. Gabapentin decreased the postoperative pain severity as well as morphine requirement and reduced incidence and severity of CRBD at 6 and 24 hours after the open prostatectomy. 

Full-Text [PDF 274 kb]   (533 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/10/25 | Accepted: 2015/10/25 | Published: 2015/10/25

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