Volume 1, Number 1 (3-2015)                   jicr 2015, 1(1): 28-32 | Back to browse issues page


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Sadeghi A, Shojapuor M, Ghassami K, Mosayebi G. The BsmI, FokI, ApaI and TaqI Polymorphisms in Vitamin D Receptor Gene in Iranian Multiple Sclerosis Patients: A Case- Control Study. jicr. 2015; 1 (1) :28-32
URL: http://jicr.arakmu.ac.ir/article-1-38-en.html

Molecular and Medicine Research Center, Department of Immunology, Arak University of Medical Sciences, Arak
Abstract:   (1245 Views)

Introduction: Multiple sclerosis (MS) is a major inflammatory and demyelinating disease of the central nervous system that is dependent on both environmental and genetic susceptibility factors. Single Nucleotide Polymorphisms (SNP) of the vitamin D receptor gene (VDRG) may be related to MS risk. Material and Methods: The BsmI, FokI, ApaI and TaqI polymorphisms in the VDRG were studied on the DNA of 80 Iranian MS patients and 50 age-matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: Our results demonstrated that genotypes frequency of the ApaI and BsmI VDR polymorphisms were significantly different between MS patients and controls (p=0.042, OR=2.5, 95%CI: 1.146-5.40 and p=0.023, OR=2.7, 95%CI: 1.08-6.75, respectively). The genotype and allele distribution of the FokI and TaqI VDRG polymorphisms did not differ between MS patients and controls. Conclusion: Our case-control study indicated that VDR ApaI and BsmI polymorphisms are more prevalent in Iranian MS patients.

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Type of Study: Research | Subject: Special
Received: 2015/03/19 | Accepted: 2015/03/19 | Published: 2015/03/19

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