year 1, Issue 2 (6-2015)                   jicr 2015, 1(2): 38-45 | Back to browse issues page

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Abstract:   (1451 Views)

Introduction: The aim of this study was to determine the effect of simultaneous administration of Teucrium polium L. extract along with glibenclamide to improve the levels of blood glucose and lipids in diabetic rats.

Methods: Forty eight male Wistar rats were randomly divided to 6 groups  (n=8): control and sham control rats received normal saline by gavage and 4 diabetic groups treated by gavage of normal saline  (diabetic control), glibenclamide  (5 mg/kg), T. polium L.  (TP) extract (200 mg/kg) and glibenclamide- T. polium L. extract combination. Diabetes was induced with intraperitoneal injection of 55 mg/kg streptozotocin  (STZ). Rats were treated at 6 weeks. At the first, middle and end of therapeutic course, blood samples were obtained. Blood glucose, triglyceride, cholesterol and body weight weremeasured. Finally, the obtained data were analyzed by SPSS 13.5 and ANOVA test.

Results: Administration of T. polium L. extract and glibenclamide significantly increased the body weight (P=0.01), decreased the plasma glucose  (P=0.001), triglyceride  (P=0.001) together with total cholesterol  (P=0.001) in comparison to diabetic rats, but simultaneous treatment with T. polium L. extract and glibenclamide had not significant difference compared to administration of separate drugs on body weight, plasma glucose, triglyceride and total cholesterol  (P>0.05).

Conclusion: Hydro-alcoholic T. polium L. extract and glibenclamide had similar effects on blood glucose and lipids in streptozotocin-induced diabetic rats however simultaneous treatment had not significant difference in this regard. 

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Type of Study: Research | Subject: Special
Received: 2015/10/25 | Accepted: 2015/10/25 | Published: 2015/10/25